2′-(4-Methylumbelliferyl)-alpha-DN-acetylneuraminic acid sodium ntsev yog ib qho tshuaj lom neeg siv hauv kev kuaj mob thiab kev tshawb fawb.Nws yog fluorescently sau npe derivative ntawm sialic acid, ib hom carbohydrate molecule pom nyob rau saum npoo ntawm cov hlwb.
Cov tshuaj no yog siv los ua ib qho substrate rau cov enzymes hu ua neuraminidases, uas ua rau tshem tawm sialic acid residues ntawm glycoproteins thiab glycolipids.Thaum cov enzymes no ua rau 2′-(4-Methylumbelliferyl)-alpha-DN-acetylneuraminic acid sodium ntsev, nws tso cov khoom fluorescent hu ua 4-methylumbelliferone.
Cov fluorescence tsim los ntawm cov compound tuaj yeem ntsuas thiab ntsuas, muab cov ntaub ntawv ntawm kev ua haujlwm ntawm neuraminidase enzymes.Qhov no yog tshwj xeeb tshaj yog pab tau nyob rau hauv txoj kev tshawb no ntawm ntau yam kab mob thiab tej yam kev mob txuam nrog aberrant sialic acid metabolism.
Cov tshuaj kuj tseem siv rau kev kuaj mob, xws li hauv kev tshawb nrhiav cov kab mob kis uas cuam tshuam nrog kev ua haujlwm ntawm neuraminidase.Nyob rau hauv cov kev ntsuam xyuas no, cov compound yog siv los txheeb xyuas qhov muaj cov kab mob tshwj xeeb lossis tshuaj xyuas cov txiaj ntsig ntawm neuraminidase inhibitors hauv kev kho tshuaj tiv thaiv kab mob.