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N, N-Bis (2-hydroxyethyl)-2-aminoethanesulfonic acid sodium ntsev CAS: 66992-27-6
N, N-Bis (2-hydroxyethyl)-2-aminoethanesulfonic acid sodium ntsev, tseem hu ua HEPES sodium ntsev, yog ib qho tshuaj lom neeg feem ntau siv los ua pH buffering tus neeg sawv cev hauv cov chaw sim tshuaj lom neeg thiab tshuaj lom neeg.Nws pab tswj kom muaj pH ruaj khov, ua rau nws zoo tagnrho rau cov ntawv thov xws li kab lis kev cai ntawm tes, kev tshuaj ntsuam enzyme, kev tshawb fawb protein, electrophoresis, thiab tshuaj formulations.HEPES sodium ntsev ua kom muaj kev pom zoo rau cov txheej txheem lom neeg thiab txhim kho qhov tseeb thiab kev ntseeg siab ntawm cov txiaj ntsig kev sim.
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2'-(4-METHYLUMBELLIFERYL)-ALPHA-DN-ACETYLNEURAMINIC ACID SODIUM ntsev CAS: 76204-02-9
2′-(4-Methylumbelliferyl)-alpha-DN-acetylneuraminic acid sodium ntsev yog ib qho tshuaj lom neeg siv hauv kev kuaj mob thiab kev tshawb fawb.Nws yog fluorescently sau npe derivative ntawm sialic acid, ib hom carbohydrate molecule pom nyob rau saum npoo ntawm cov hlwb.
Cov tshuaj no yog siv los ua ib qho substrate rau cov enzymes hu ua neuraminidases, uas ua rau tshem tawm sialic acid residues ntawm glycoproteins thiab glycolipids.Thaum cov enzymes no ua rau 2′-(4-Methylumbelliferyl)-alpha-DN-acetylneuraminic acid sodium ntsev, nws tso cov khoom fluorescent hu ua 4-methylumbelliferone.
Cov fluorescence tsim los ntawm cov compound tuaj yeem ntsuas thiab ntsuas, muab cov ntaub ntawv ntawm kev ua haujlwm ntawm neuraminidase enzymes.Qhov no yog tshwj xeeb tshaj yog pab tau nyob rau hauv txoj kev tshawb no ntawm ntau yam kab mob thiab tej yam kev mob txuam nrog aberrant sialic acid metabolism.
Cov tshuaj kuj tseem siv rau kev kuaj mob, xws li hauv kev tshawb nrhiav cov kab mob kis uas cuam tshuam nrog kev ua haujlwm ntawm neuraminidase.Nyob rau hauv cov kev ntsuam xyuas no, cov compound yog siv los txheeb xyuas qhov muaj cov kab mob tshwj xeeb lossis tshuaj xyuas cov txiaj ntsig ntawm neuraminidase inhibitors hauv kev kho tshuaj tiv thaiv kab mob.
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TAPSO CAS: 68399-81-5 Chaw tsim tshuaj paus Nqe
TAPSO (3-[N-tris(hydroxymethyl)methyl]amino]-2-hydroxypropanesulfonic acid) yog ib qho zwitterionic tsis siv feem ntau siv hauv kev tshawb fawb lom neeg thiab biochemical.Nws yog tus neeg sawv cev zoo nrog pKa ze ntawm lub cev pH, ua rau nws tsim nyog rau kev tswj hwm pH ruaj khov hauv kev sim tshuaj lom neeg.TAPSO feem ntau yog siv rau hauv kev ua kom huv ntawm cov protein, tshuaj ntsuam enzyme, kab lis kev cai ntawm tes, thiab daim ntawv thov electrophoresis.Nws cov dej solubility siab thiab tsis cuam tshuam nrog cov txheej txheem lom neeg ua rau nws muaj kev xaiv nrov hauv zej zog kev tshawb fawb.TAPSO paub txog nws qhov tsawg kawg nkaus ntawm kev ua haujlwm enzyme thiab feem ntau yog siv los ua lwm txoj hauv kev rau lwm cov tshuaj tiv thaiv xws li Tris lossis phosphate buffers.
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N-Acetyl-L-cysteine CAS: 616-91-1
N-Acetyl-L-cysteine (NAC) yog ib daim ntawv hloov kho ntawm cov amino acid cysteine.Nws muab ib qho chaw ntawm cysteine thiab tuaj yeem hloov mus rau hauv tripeptide glutathione, muaj zog antioxidant hauv lub cev.NAC paub txog nws cov khoom antioxidant thiab mucolytic, ua rau nws muaj txiaj ntsig zoo hauv ntau daim ntawv thov kev noj qab haus huv.
Raws li ib qho antioxidant, NAC pab tiv thaiv cov hlwb los ntawm kev puas tsuaj los ntawm cov dawb radicals, reactive oxygen hom, thiab co toxins.Nws kuj txhawb nqa glutathione synthesis, uas ua lub luag haujlwm tseem ceeb hauv lub cev cov txheej txheem detoxification thiab tswj lub cev tsis muaj zog.
NAC tau kawm txog nws cov txiaj ntsig zoo hauv kev ua pa, tshwj xeeb tshaj yog rau cov tib neeg uas muaj mob xws li mob ntsws ntev, COPD, thiab cystic fibrosis.Nws yog feem ntau siv los ua ib qho expectorant los pab nyias thiab loosen cov hnoos qeev, ua kom yooj yim rau tshem tawm cov pa.
Tsis tas li ntawd, NAC tau pom cov lus cog tseg hauv kev txhawb nqa lub siab kev noj qab haus huv los ntawm kev pab tshem tawm cov tshuaj lom, xws li acetaminophen, ib qho tshuaj tua kab mob.Nws kuj tseem muaj peev xwm tiv thaiv lub siab puas tsuaj los ntawm kev haus cawv.
Ntxiv nrog rau nws cov tshuaj tiv thaiv antioxidant thiab kev ua pa, NAC tau tshawb fawb txog nws cov txiaj ntsig zoo hauv kev puas siab puas ntsws.Qee qhov kev tshawb fawb qhia tias nws yuav muaj kev cuam tshuam zoo rau kev xav tsis zoo, xws li kev nyuaj siab thiab obsessive-compulsive disorder (OCD).
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PIPES CAS: 5625-37-6 Chaw tsim tshuaj paus Nqe
PIPES (piperazine-1,4-bisethanesulfonic acid) yog ib qho zwitterionic buffering compound feem ntau siv hauv kev tshawb fawb lom thiab biochemical.Nws yog ib qho pH tsis zoo nrog lub peev xwm siab rau kev tswj xyuas pH ruaj khov hauv pH ntau ntawm 6.1 txog 7.5.PIPES muaj kev cuam tshuam tsawg heev rau biomolecules thiab tsim nyog rau kev ntsuas kub ntawm qhov ntsuas kub.Nws yog feem ntau siv nyob rau hauv gel electrophoresis cov tswv yim thiab tshuaj formulation ua ib tug stabilizing neeg sawv cev.Zuag qhia tag nrho, PIPES yog ntau yam thiab siv dav hauv ntau qhov chaw sim.
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2′,6′-DiMethylcarbonylphenyl-10-sulfopropylacridiniuM-9-carboxylate 4′-NHS Ester CAS: 194357-64-7
2′,6′-DiMethylcarbonylphenyl-10-sulfopropylacridinium-9-carboxylate 4′-NHS ester yog cov tshuaj sib xyaw nrog cov qauv molecular complex.Nws muaj ib pawg sulfopropylacridinium thiab ib pawg carboxylate ester ua haujlwm.Lub xub ntiag ntawm ester moiety qhia tau hais tias nws yog reactive thiab yuav siv tau raws li ib tug labeling los yog hloov tus neeg sawv cev rau biomolecules.
Cov pab pawg neeg sulfopropylacridinium qhia tias nws yuav muaj peev xwm siv tau hauv kev tshuaj ntsuam fluorescence, qhov twg nws tuaj yeem siv los ua fluorescent sojntsuam lossis zas xim rau kev kuaj thiab tshuaj xyuas biomolecules.Nws kuj tseem yuav muaj feem cuam tshuam rau hauv kev tshawb fawb ntawm cov txheej txheem ntawm tes, xws li cov teeb liab calcium intracellular.
Kev suav nrog NHS ester pawg qhia tau hais tias nws tuaj yeem hnov mob nrog thawj amines, xws li cov pom muaj nyob hauv cov proteins lossis peptides, los tsim cov nyiaj ruaj khov amide.Qhov no reactivity ua rau nws muaj txiaj ntsig zoo rau kev siv bioconjugation, qhov twg nws tuaj yeem siv los sau lossis hloov biomolecules nrog rau lwm cov khoom siv molecules, xws li fluorophores lossis cov cim npe.
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5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide CAS: 4264-82-8
5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide yog ib qho chaw siv nyob rau hauv ntau yam kev tshawb fawb biochemical, tshwj xeeb tshaj yog rau kev kuaj pom thiab pom kev ua haujlwm ntawm enzyme.Nws yog ib qho substrate uas tuaj yeem hydrolyzed los ntawm cov enzymes tshwj xeeb, uas ua rau tso tawm cov khoom muaj xim lossis fluorescent.
Cov tshuaj no feem ntau siv rau hauv kev tshuaj ntsuam xyuas kom pom qhov muaj thiab kev ua haujlwm ntawm cov enzymes xws li beta-galactosidase thiab beta-glucuronidase.Cov enzymes no tshem tawm cov acetyl thiab glucosaminide pawg los ntawm cov substrate, ua rau tsim cov xim xiav lossis ntsuab chromophore.
Cov qauv tshwj xeeb ntawm 5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide tso cai rau kev tshawb nrhiav tau yooj yim thiab kom muaj nuj nqis ntawm kev ua enzyme.Nws siv nyob rau hauv ntau yam kev sim, suav nrog histochemistry, immunohistochemistry, thiab kev soj ntsuam ntawm tes, tau ua rau muaj kev nkag siab zoo ntawm kev ua haujlwm enzyme.
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Sodium ntsev ntsev CAS: 139-41-3 Chaw tsim tshuaj paus Nqe
N, N-Bis (2-hydroxyethyl) glycine sodium ntsev yog tshuaj lom neeg siv los ua tus neeg sawv cev buffering nyob rau hauv ntau yam kev siv biochemical thiab biophysical.Nws pab tswj kom muaj qib pH ruaj khov hauv kev sim, ua kom muaj txiaj ntsig zoo hauv kev tshawb fawb enzyme, kev tshawb fawb protein, kab lis kev cai ntawm tes, thiab Western blotting cov tswv yim.
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Spinosad CAS: 131929-60-7 Chaw tsim tshuaj paus
Spinosad yog ib pab pawg 5 nicotinic acetylcholine receptor agonist, uas ua rau cov leeg tsis muaj zog thiab tshee hnyo rau lub cev muaj zog neuron.Kev raug mob ntev ua rau tuag tes tuag taw thiab yoov tuag.Flea tuag pib li ntawm 30 feeb ntawm kev noj tshuaj thiab hauv 4 teev ua tiav.Spinosad tsis cuam tshuam nrog cov chaw sib txuas ntawm lwm cov tshuaj tua kab (GABA-ergic lossis nicotinic).
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Rotenone CAS: 83-79-4 Chaw tsim tshuaj paus
Rotenone yog ob qho tib si lub plab thiab tiv tauj tshuaj lom rau arthropods.Nws qhov kev txiav txim siab nrawm nrawm yog vim qhov txo qis ntawm nicotinamide adenine dinucleotide los ua tus cofactor hauv ntau txoj hauv kev biochemical suav nrog Krebs lub voj voog, yog li inhibiting mitochondrial respiratory enzymes.
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Diazinon CAS: 333-41-5 Chaw tsim tshuaj paus
Diazinon muaj nyob rau hauv daim ntawv ntawm cov xim tsis muaj xim lossis xim av tsaus.Nws yog soluble me ntsis hauv dej tab sis soluble hauv roj av ether, cawv, thiab benzene.Diazinon yog siv los tswj ntau yam kev ua liaj ua teb thiab cov kab tsuag hauv tsev.Cov no suav nrog cov kab tsuag hauv av, ntawm cov nroj tsuag ornamental, txiv hmab txiv ntoo, zaub, thiab qoob loo thiab cov kab tsuag hauv tsev xws li yoov, fleas, thiab kab laum.
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Avermectin CAS: 71751-41-2 Chaw tsim tshuaj paus
Abamectin (Avermectin) yog cov kab mob toxicosis.Nws lub hom phiaj yog tsom mus rau GABAA receptor ntawm kab neuron synapse lossis neuromuscular synapse, cuam tshuam nrog cov ntaub ntawv hloov pauv ntawm cov paj hlwb, uas yog txhawb cov paj hlwb kom tso tawm cov neurotransmitter inhibitor γ-aminobutyric acid (GA-BA), ua rau muaj kev qhib dav dav ntawm GABA-gated chloride channel nrog chloride channel-ua kom cov nyhuv.
