Candesartana Cilexetila CAS: 145040-37-5

Candesartan cilexetil yog ib qho tshuaj prodrug ntawm candesartan, uas muaj zog, ua haujlwm ntev, thiab xaiv tau angiotensin II hom 1 receptor AT1 antagonist. Nws raug hydrolyzed sai sai rau candesartan thaum lub sijhawm nqus los ntawm txoj hnyuv. Tom qab hydrolysis ntawm candesartan cilexetil rau candesartan thaum lub sijhawm nqus los ntawm txoj hnyuv, candesartan xaiv sib tw nrog angiotensin II rau kev khi ntawm angiotensin II receptor subtype 1 AT1 hauv cov leeg nqaij du, thaiv angiotensin II-mediated vasoconstriction thiab ua rau vasodilation. Tsis tas li ntawd, kev tawm tsam ntawm AT1 hauv adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis thiab secretion los ntawm adrenal cortex; sodium thiab dej excretion nce ntxiv, ua raws li kev txo qis hauv plasma ntim thiab ntshav siab.