Candesartana Cilexetila CAS: 145040-37-5

Candesartan cilexetil yog ib qho tshuaj ntawm lub zog, ua haujlwm ntev, thiab xaiv angiotensin II hom 1 receptor AT1 antagonist, candesartan.Nws yog hydrolyzed sai sai rau candesartan thaum lub plab zom mov.Tom qab hydrolysis ntawm candesartan cilexetil rau candesartan thaum lub sij hawm plab hnyuv nqus, candesartan xaiv sib tw nrog angiotensin II rau kev khi ntawm angiotensin II receptor subtype 1 AT1 hauv vascular du nqaij, thaiv angiotensin II-mediated vasoconstriction thiab inducing vasodilatation.Tsis tas li ntawd, antagonism ntawm AT1 nyob rau hauv lub qog adrenal inhibits angiotensin II-stimulated aldosterone synthesis thiab tso tawm los ntawm adrenal cortex;sodium thiab dej excretion nce, tom qab ntawd txo qis hauv cov ntshav ntim thiab ntshav siab.