Tom ntej: 4-Nitrophenyl Beta-D-glucuronide CAS: 10344-94-2

Kev kuaj pom ntawm β-glucuronidase kev ua haujlwm: 4-NPBG feem ntau yog siv los ua cov chromogenic substrate los ntsuas qhov muaj thiab kev ua haujlwm ntawm β-glucuronidase hauv ntau cov qauv lom.Lub enzyme cleaves glycosidic daim ntawv cog lus ntawm 4-NPBG, tsim 4-nitrophenol, uas yuav ntsuas tau siv spectrophotometric.

Kev tshawb fawb txog tshuaj metabolism: Txij li β-glucuronidase ua lub luag haujlwm tseem ceeb hauv cov metabolism hauv cov tshuaj thiab xenobiotics, 4-NPBG tuaj yeem siv los ntsuas cov haujlwm ntawm cov enzyme no hauv cov tshuaj metabolism hauv kev tshawb fawb.Nws pab kom nkag siab txog qhov twg thiab kinetics ntawm cov tshuaj tiv thaiv glucuronidation, uas yog qhov tseem ceeb rau kev tshem tawm tshuaj thiab bioavailability.

Kev tshawb fawb Toxicology: Qee cov tshuaj toxicological tuaj yeem metabolized thiab tawm hauv daim ntawv ntawm glucuronide conjugates.Los ntawm kev siv 4-NPBG ua ib lub substrate, cov kws tshawb fawb tuaj yeem tshuaj xyuas cov haujlwm ntawm β-glucuronidase hauv cov ntaub so ntswg sib txawv lossis cov kab ntawm tes los ntsuas qhov muaj peev xwm toxicity lossis tsis zoo ntawm cov tebchaw.

Kev kuaj mob hauv tsev kho mob: Kev ntsuas ntawm β-glucuronidase kev ua haujlwm siv 4-NPBG tuaj yeem siv rau hauv chaw kho mob txhawm rau kuaj xyuas qee yam kab mob lossis mob.Cov qib txawv txav lossis kev ua haujlwm ntawm β-glucuronidase tuaj yeem qhia qee yam kab mob caj ces, lub siab ua haujlwm tsis zoo, lossis mob qog noj ntshav.