Tritylolmesartanethylester CAS: 144690-33-5

Tritylolmesartanethylester muaj qhov tseem ceeb heev hauv kev kho mob thiab kev tshawb nrhiav tshuaj, tshwj xeeb tshaj yog hauv kev tsim cov angiotensin II receptor antagonists nrog cov ntaub ntawv pharmacological zoo dua. Raws li ib qho derivative ntawm cov tshuaj antihypertensive paub zoo olmesartan medoxomil, cov tshuaj no ua haujlwm ua lub scaffold muaj txiaj ntsig rau kev tsim thiab kev soj ntsuam ntawm cov analogs tshiab nrog kev ua tau zoo dua thiab cov khoom pharmacokinetic. Hauv kev tshawb fawb txog kev kho mob, Tritylolmesartanethylester raug kawm txog nws lub peev xwm los hloov kho lub renin-angiotensin system, uas ua lub luag haujlwm tseem ceeb hauv kev tswj cov ntshav siab, cov kua dej sib npaug, thiab kev ua haujlwm ntawm lub plawv. Los ntawm kev tshawb nrhiav nws cov kev sib cuam tshuam nrog angiotensin II receptors, cov kws tshawb fawb lub hom phiaj los tsim cov tshuaj tshiab uas tuaj yeem thaiv cov teebmeem ntawm physiological ntawm angiotensin II, ua rau kev tsim cov tshuaj antihypertensive tiam tom ntej nrog cov txiaj ntsig kho mob zoo dua thiab txo cov kev phiv. Ntxiv mus, kev hloov kho cov qauv thiab kev soj ntsuam pharmacological ntawm Tritylolmesartanethylester thiab nws cov analogs pab txhawb rau kev nkag siab txog kev sib raug zoo ntawm cov qauv-kev ua ub no (SAR) hauv chav kawm angiotensin receptor antagonist. Cov kev paub no coj kev tsim qauv zoo ntawm cov tshuaj uas zoo tshaj plaws nrog kev txhim kho kev sib txuas lus ntawm cov receptor, kev xaiv, thiab kev ruaj khov ntawm cov metabolism, ua rau txoj hauv kev rau kev nce qib hauv kev kho mob ntawm cov kab mob plawv xws li ntshav siab, lub plawv tsis ua haujlwm, thiab mob ntshav qab zib nephropathy. Ntxiv mus, Tritylolmesartanethylester cov ntawv thov muaj peev xwm nthuav dav mus rau kev tshawb fawb ua ntej uas tsom mus rau kev piav qhia nws cov ntaub ntawv pharmacokinetic thiab pharmacodynamic, cov ntaub ntawv lom, thiab lub peev xwm kho mob los ntawm kev sim hauv vitro thiab hauv vivo. Cov kev tshawb fawb no muab cov ntaub ntawv tseem ceeb rau kev ntsuas nws qhov kev nyab xeeb thiab kev ua haujlwm, thaum kawg txhawb nqa nws txoj kev nce qib mus rau kev sim tshuaj thiab kev tsim tshuaj muaj peev xwm. Hauv kev xaus, Tritylolmesartanethylester siv suav nrog nws lub luag haujlwm tseem ceeb hauv kev tshuaj lom neeg thiab kev tshawb fawb tshuaj ua lub platform rau kev tsim, kev sib xyaw, thiab kev ntsuas ntawm cov tshuaj angiotensin II receptor antagonists tshiab, pab txhawb rau kev nce qib ntawm kev kho mob ntshav siab thiab kev kho mob plawv.