Tetrabenzyl Dapagliflozin CAS: 2001088-28-2

Ua los ntawm cov txheej txheem organic tshwj xeeb, tetrabenzyl dapagliflozin muaj cov qauv molecular nyuaj uas tseem ceeb rau nws cov ntawv thov ntau yam. Qhov muaj plaub benzyl substituents ntawm dapagliflozin core cuam tshuam rau nws cov tshuaj reactivity, solubility, thiab kev sib cuam tshuam nrog cov kab ke hauv lub cev. Cov yam ntxwv ntawm cov qauv no yog qhov tseem ceeb rau kev nkag siab txog nws cov ntaub ntawv pharmacological thiab lub peev xwm kho mob. Daim ntawv thov hauv Cov Tshuaj Cov tshuaj no muaj kev cia siab hauv kev tshawb fawb txog tshuaj vim nws cov qauv sib xyaw. Dapagliflozin derivatives, paub txog lawv lub luag haujlwm ua sodium-glucose co-transporter 2 (SGLT2) inhibitors, yog siv rau hauv kev kho mob hom 2 ntshav qab zib mellitus. Cov benzyl hloov pauv ntawm tetrabenzyl dapagliflozin tuaj yeem hloov kho nws cov khoom pharmacokinetic lossis txhim kho nws cov kev xaiv thiab kev ua haujlwm zoo li SGLT2 inhibitor. Kev Ua Haujlwm thiab Cov Txheej Txheem ntawm Lub Cev Kev Tshawb Fawb qhia tias dapagliflozin thiab nws cov derivatives siv lawv cov txiaj ntsig kho mob los ntawm kev txwv SGLT2 hauv cov raj xa dej proximal, yog li txo cov ntshav qab zib reabsorption thiab nce cov zis glucose excretion. Cov pab pawg benzyl ntawm tetrabenzyl dapagliflozin tej zaum yuav cuam tshuam rau nws lub zog, kev ruaj khov ntawm cov metabolism, lossis kev sib cuam tshuam nrog cov receptors tawm ntawm lub hom phiaj, cuam tshuam rau nws cov ntaub ntawv pharmacological tag nrho. Cov Kev Tsim Khoom thiab Kev Txhim Kho Kev tsim cov tetrabenzyl dapagliflozin cuam tshuam nrog cov txheej txheem organic nyuaj pib los ntawm dapagliflozin thiab benzyl halides lossis benzyl alcohols. Kev ua kom zoo tshaj plaws ntawm cov kev tsim khoom yog qhov tseem ceeb rau kev ua tiav qhov huv siab thiab cov txiaj ntsig, tseem ceeb rau kev siv tshuaj. Ntxiv mus, kev kho cov txheej txheem tsim khoom txhim kho kev nthuav dav, kev siv nyiaj tsim nyog, thiab kev ruaj khov hauv kev tsim tshuaj. Kev Tshawb Fawb Tam Sim No thiab Cov Lus Qhia Yav Tom Ntej Cov kev siv zog tshawb fawb tam sim no tsom mus rau kev tshawb nrhiav tetrabenzyl dapagliflozin lub peev xwm dhau ntawm kev kho mob ntshav qab zib, suav nrog nws daim ntawv thov hauv cov kab mob plawv lossis cov kab mob metabolic. Cov kev tshawb fawb yav tom ntej yuav tshawb nrhiav kev hloov kho rau nws cov qauv los txhim kho bioavailability, txo cov kev mob tshwm sim, lossis tsom mus rau lwm txoj hauv kev kho mob. Kev sim tshuaj thiab kev tshawb fawb ua ntej tseem tab tom ua kom ntsuas nws qhov kev nyab xeeb, kev ua tau zoo, thiab cov teebmeem mus sij hawm ntev. Xaus Lus Xaus lus, tetrabenzyl dapagliflozin sawv cev rau ib qho tshuaj tseem ceeb hauv kev tshuaj lom neeg thiab kev tshawb fawb txog tshuaj vim nws cov qauv tshuaj sib txawv thiab cov peev xwm siv tau rau kev kho mob. Kev koom ua ke ntawm plaub pawg benzyl rau hauv lub moj khaum dapagliflozin qhia txog nws qhov kev hloov pauv thiab kev cog lus pharmacological, tshwj xeeb tshaj yog nyob rau hauv cov kab mob zoo li hom 2 ntshav qab zib mellitus. Kev txhim kho kev tshawb fawb txog nws cov khoom siv tshuaj, kev sib cuam tshuam ntawm cov kab mob, thiab cov txheej txheem tsim khoom yog qhov tseem ceeb rau kev ua kom nws muaj peev xwm kho mob thiab nthuav dav nws cov ntawv thov hauv kev kho mob.