S)-(+)-Camptothecin CAS: 7689-03-4

(S) -(+)-Camptothecin muaj kev cia siab rau kev kho mob qog noj ntshav ntau yam, tshwj xeeb tshaj yog hauv thaj chaw ntawm kev kho mob qog noj ntshav. Nws txoj kev ua haujlwm suav nrog kev tsom mus rau thiab tiv thaiv kev ua haujlwm ntawm topoisomerase I, ib qho enzyme tseem ceeb rau kev tshem tawm DNA thaum lub sijhawm faib cell. Los ntawm kev cuam tshuam cov txheej txheem no, (S) -(+) - Camptothecin tiv thaiv cov cell qog noj ntshav los ntawm kev rov ua dua thiab loj hlob, thaum kawg ua rau apoptosis lossis programmed cell tuag. Cov tshuaj no tau ua pov thawj tias muaj txiaj ntsig zoo tiv thaiv ntau hom qog noj ntshav, suav nrog colorectal, ovarian, thiab me me cell ntsws cancer, ntawm lwm yam. Kev tshawb fawb tau tsom mus rau kev tsim cov derivatives thiab formulations ntawm (S) -(+) - Camptothecin los txhim kho nws cov solubility thiab bioavailability, txhim kho nws cov txiaj ntsig kho mob. Cov kev tshawb fawb kho mob thiab kev sim tau tshawb nrhiav (S) -(+) - Camptothecin siv ua ib tus neeg sawv cev lossis ua ke nrog lwm cov neeg sawv cev kho mob kom ua kom nws cov teebmeem tiv thaiv qog noj ntshav ntau tshaj plaws thaum txo qis cov kev tsis zoo. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias (S)-(+)-Camptothecin tej zaum yuav muaj kev lom thiab cov kev mob tshwm sim, uas yuav tsum tau saib xyuas thiab tswj hwm los ntawm cov kws kho mob. Kev tshawb nrhiav ntawm (S)-(+)-Camptothecin thiab nws cov khoom siv txuas ntxiv tsav kev nce qib hauv kev kho mob qog noj ntshav, muab kev cia siab rau kev txhim kho cov txiaj ntsig kho mob thiab lub neej zoo rau cov neeg mob uas tawm tsam ntau yam kab mob qog noj ntshav.