Protein Kinase Supplement KT5823 CAS: 126643-37-6

Cov tshuaj ntxiv Protein kinase KT5823 yog ib qho tshuaj inhibitor ntawm protein kinase G (PKG) uas feem ntau siv, tshwj xeeb tshaj yog tsom mus rau hom I isoform PKG-1. PKG yog serine/threonine kinase uas ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem cellular xws li kev so cov leeg nqaij du, platelet aggregation, thiab kev tswj hwm ntawm vasodilation.

Qhov cuam tshuam tseem ceeb ntawm KT5823 yog kev txwv tsis pub PKG-1 ua haujlwm los ntawm kev sib tw nrog ATP khi rau kinase domain. Los ntawm kev txwv PKG-1, KT5823 tuaj yeem cuam tshuam cov kev taw qhia signaling downstream ntawm PKG-1 activation, suav nrog cGMP-dependent signaling cascades.

Daim ntawv thov ntawm KT5823 yog feem ntau hauv kev tshawb fawb los tshawb nrhiav kev ua haujlwm thiab kev taw qhia ntawm PKG-1. Nws siv rau hauv kev txwv tsis pub PKG-1 ua haujlwm tso cai rau cov kws tshawb fawb los tshawb nrhiav lub luag haujlwm ntawm PKG-1 hauv ntau yam kev ua haujlwm ntawm lub cev thiab kab mob. Qee qhov kev siv tshwj xeeb ntawm KT5823 suav nrog:

Kev Tshawb Fawb Txog Kev So Cov Nqaij Mos Mos: PKG-1 ua lub luag haujlwm tseem ceeb hauv kev so cov nqaij mos mos. Los ntawm kev txwv PKG-1 siv KT5823, cov kws tshawb fawb tuaj yeem kawm txog cov txheej txheem thiab txoj hauv kev uas cuam tshuam nrog kev so cov nqaij mos mos, uas yog qhov tseem ceeb hauv cov teb xws li kev tshawb fawb txog lub plawv.

Kev kawm txog kev sib sau ua ke ntawm cov ntshav platelet: PKG-1 kuj tswj cov ntshav platelet sib sau ua ke thiab kev tsim cov ntshav txhaws. Kev txwv PKG-1 nrog KT5823 tso cai rau cov kws tshawb fawb los soj ntsuam qhov cuam tshuam ntawm PKG-1 kev ua haujlwm ntawm cov ntshav platelet thiab nkag siab txog cov kev koom tes.

Tshawb nrhiav cov hom phiaj ntawm PKG-1: Los ntawm kev txwv PKG-1, cov kws tshawb fawb tuaj yeem txheeb xyuas thiab kawm cov hom phiaj thiab cov neeg ua haujlwm ntawm PKG-1 signaling, muab kev nkag siab rau cov txheej txheem molecular hauv qab PKG-1-mediated cellular responses.