PhentolamineMesylate CAS: 65-28-1

Phentolamine mesylate ua haujlwm ntau yam tseem ceeb hauv kev siv kho mob thiab kev tshawb fawb. Ua ib qho tshuaj vasodilator thiab tshuaj tiv thaiv ntshav siab, nws siv rau kev kho mob thaum muaj xwm txheej ceev ntawm ntshav siab, tshwj xeeb tshaj yog thaum muaj teeb meem pheochromocytoma, qhov twg yuav tsum txo cov ntshav siab sai. Nws kuj pom tias muaj txiaj ntsig zoo hauv kev tswj hwm cov kab mob ntshav siab uas tshwm sim los ntawm iatrogenic catecholamine thaum lub sijhawm phais thiab lwm yam kev kho mob. Hauv kev kho hniav, phentolamine mesylate siv ua tus neeg sawv cev rov qab los ntawm kev siv tshuaj loog hauv zos, pab tswj kev siv tshuaj loog rau cov nqaij mos tom qab kev kho hniav uas muaj cov tshuaj loog hauv zos uas muaj cov tshuaj vasoconstrictor xws li epinephrine. Nws cov teebmeem vasodilatory pab txo cov ntshav ntws hauv zos thiab ua kom cov ntshav ntws rov qab zoo li qub. Ntxiv mus, cov tshuaj no siv rau hauv cov txheej txheem kuaj mob xws li kev tiv thaiv thiab kho cov dermal necrosis uas tshwm sim los ntawm kev siv cov tshuaj vasoactive, ua kom cov nqaij ntws zoo. Ntxiv mus, nws koom nrog kev tshawb fawb thiab kev sim tshuaj hauv chaw kho mob uas tshawb nrhiav nws cov kev siv tau hauv cov mob ntsig txog kev tsis txaus ntawm cov hlab ntsha, kev ua haujlwm tsis zoo ntawm lub cev, thiab Raynaud's phenomenon, pab txhawb rau kev nce qib hauv kev kho mob plawv thiab urological. Lub luag haujlwm ntawm Phentolamine mesylate nthuav dav mus rau qhov chaw sim ua ib qho cuab yeej hauv kev tshawb fawb txog tshuaj thiab kev ua haujlwm ntawm lub cev, pab tshawb nrhiav kev ua haujlwm ntawm adrenergic receptor, cov lus teb ntawm cov hlab ntsha, thiab kev hloov pauv ntawm cov haujlwm ntawm lub paj hlwb sympathetic. Nws lub peev xwm los thaiv adrenergic receptors thiab cuam tshuam rau lub suab vascular pab txhawb rau kev nkag siab txog lub cev cardiovascular thiab kev txhim kho cov kev kho mob uas tsom mus rau adrenergic signaling pathways. Zuag qhia tag nrho, phentolamine mesylate cov ntawv thov sib txawv qhia txog nws qhov tseem ceeb hauv kev kho mob hauv tsev kho mob, kev kho hniav, kev tshawb fawb, thiab kev tsim tshuaj, qhia txog nws lub peev xwm los pab txhawb rau kev tswj hwm cov mob plawv thiab kev nce qib ntawm kev paub txog kev tshawb fawb txog adrenergic receptor function thiab kev tswj hwm cov hlab ntsha.