Nigericin CAS: 28380-24-7

Nigericin tau siv dav hauv cov chaw soj ntsuam los kawm txog cov txheej txheem thauj cov ion hauv lub cev, kev tswj hwm lub peev xwm ntawm daim nyias nyias, thiab kev hloov pauv pH hauv lub hlwb. Nws cov khoom ionophoric ua rau nws yog ib qho cuab yeej muaj txiaj ntsig rau kev tshawb nrhiav cov kab ke ion, daim nyias nyias permeability, thiab lub cev homeostasis. Cov kws tshawb fawb feem ntau siv nigericin los tswj cov ion concentration hauv cov hlwb thiab tshawb nrhiav nws cov teebmeem rau kev ua haujlwm ntawm lub hlwb thiab kev muaj sia nyob. Ntxiv rau nws cov ntawv thov kev tshawb fawb, nigericin tau qhia txog cov khoom tiv thaiv kab mob qog noj ntshav zoo los ntawm kev ua rau apoptosis (kev tuag ntawm cov hlwb programmed) hauv cov hlwb qog noj ntshav. Cov kev tshawb fawb tau qhia txog nigericin lub peev xwm los tiv thaiv cov hlwb qog noj ntshav loj hlob, ua rau mitochondrial dysfunction, thiab cuam tshuam cov kab ke oncogenic signaling. Cov kev tshawb pom no qhia txog kev siv nigericin ua tus neeg sawv cev kho mob rau qee hom mob qog noj ntshav, qhia txog nws lub luag haujlwm hauv kev tshawb fawb txog mob qog noj ntshav thiab kev tsim tshuaj. Txawm hais tias nigericin muaj kev cia siab hauv kev tshawb fawb thiab kev tshawb fawb txog mob qog noj ntshav, nws cov haujlwm muaj zog hauv lub cev xav tau kev tuav thiab tswj kev siv hauv chaw kuaj mob. Cov kws tshawb fawb ua haujlwm nrog nigericin yuav tsum ua raws li cov lus qhia kev nyab xeeb thiab cov txheej txheem kom ntseeg tau tias muaj kev tswj hwm thiab pov tseg kom raug. Kev koom tes nrog cov kws tshaj lij thiab ua raws li cov txheej txheem tsim tsa yog qhov tseem ceeb thaum siv nigericin rau kev tshawb fawb lossis tshawb nrhiav nws lub peev xwm kho mob hauv ntau yam kev siv biomedical.