Natamycin/Pimaricin CAS: 7681-93-8 Chaw Tsim Khoom Siv

Pimaricin yog ib qho macrocyclic tetraene uas tau rho tawm los ntawm Streptomyces natalensis xyoo 1957. Pimaricin ua rau pom kev ua haujlwm tiv thaiv kab mob fungal ntau yam tiv thaiv cov poov xab thiab cov kab mob filamentous los ntawm kev khi tshwj xeeb rau ergosterol los thaiv kev loj hlob ntawm cov kab mob fungal. Tsis zoo li cov polyenes cuam tshuam, nystatin thiab filipin, pimaricin tsis hloov pauv qhov permeability ntawm cov plasma membrane. Pimaricin siv rau hauv kev lag luam khoom noj khoom haus rau kev kho qhov chaw ntawm cov cheeses ua tus inhibitor pwm. Natamycin yog ib qho semisynthetic polyene tshuaj tua kab mob. Natamycin tsis yaj hauv dej thiab yuav tsis nkag mus rau hauv lub corneal epithelium. Natamycin yog tib tus neeg sawv cev antifungal uas tau pom zoo rau kev siv rau ntawm lub qhov muag thiab tib lub tshuaj muag muag rau kev kho mob fungal keratitis. Natamycin, tseem hu ua pimaracin, koom nrog tsev neeg polyene ntawm cov tshuaj tua kab mob; (ib pawg ntawm cov neeg sawv cev antifungal uas tsom thiab khi rau eukaryotic sterols thiab tshwj xeeb tshaj yog ergosterol), thiab nws yog ib qho metabolite thib ob ntawm Streptomyces natalensis.