Leflunomide CAS: 75706-12-6 Chaw Tsim Khoom

Leflunomide yog ib yam tshuaj kho mob rheumatic uas muaj peev xwm hloov kho kab mob thiab tau tsim tawm los ua Arava hauv Tebchaws Meskas rau kev kho mob rheumatoid arthritis (RA); nws yog thawj zaug thiab tib yam tshuaj uas tau qhia kom qeeb qeeb kev puas tsuaj ntawm cov pob qij txha ntawm RA, yog li daws qhov kev xav tau kev kho mob uas tsis tau txais kev pab. Leflunomide yog ib yam tshuaj pro-drug uas metabolized sai thiab yuav luag tag nrho (ib nrab lub neej, <60 feeb) tom qab noj teriflunomide, uas yog cov metabolite pharmacologically active α-cyanoenol.

Txiav txim los yog Thov Kev Hais Nqe

Cov Lus Qhia Txog Khoom

Cov Cim Npe Khoom

Daim Ntawv Thov thiab Cov Nyhuv

Leflunomide tsis ua haujlwm, tab sis teriflunomide tiv thaiv pyrimidine de novo synthesis ntawm cov tshuaj kho mob qis los ntawm kev tiv thaiv dihydroorotate dehydrogenase (cov enzyme txiav txim siab tus nqi rau kev tsim UMP), txo qis DNA thiab RNA synthesis, thiab nres lub voj voog ntawm kev loj hlob ntawm cov cell thiab kev tsim cov tshuaj tiv thaiv. Kev txo qis ntawm dihydroorotate mus rau orotate tshwm sim ua ke nrog kev txo qis ntawm nws cov cofactor, ubiquinone (coenzyme Q). Kev txwv tsis pub dihydroorotate dehydrogenase los ntawm teriflunomide qhia tau hais tias kinetics tsis sib tw thiab tsis sib tw. Kev siv leflunomide rau cov neeg mob uas muaj mob rheumatoid arthritis ua rau muaj kev tshem tawm cov B cell thiab txo qis ntawm cov txheej txheem tiv thaiv kab mob.

Qauv Khoom

Khoom Ntim:

Cov Lus Qhia Ntxiv:

Kev sau ua ke	C12H9F3N2O2
Kev Ntsuas	99%
Qhov tsos	Hmoov dawb
CAS Nr.	75706-12-6
Ntim khoom	25KG
Lub Neej Txee	2 xyoos
Kev Khaws Cia	Khaws cia rau qhov chaw txias thiab qhuav
Daim Ntawv Pov Thawj	ISO.