Leflunomide CAS: 75706-12-6 Chaw tsim tshuaj paus

Leflunomide yog ib hom kab mob ntawm qhov ncauj-hloov tshuaj tiv thaiv kab mob thiab tau pib ua Arava hauv Asmeskas rau kev kho mob rheumatoid mob caj dab (RA);Nws yog thawj zaug thiab tsuas yog cov tshuaj uas yuav tsum tau qhia kom qeeb cov txheej txheem kev sib koom ua ke ntawm RA, yog li hais txog kev xav tau kev kho mob tsis haum.Leflunomide yog cov tshuaj tiv thaiv sai thiab yuav luag tag nrho metabolized (ib nrab-lub neej, <60 feeb) tom qab qhov ncauj Kev tswj hwm rau teriflunomide, lub pharmacologically active α-cyanoenol metabolite.

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Leflunomide tsis ua haujlwm, tab sis teriflunomide inhibits pyrimidine de novo synthesis ntawm cov tshuaj kho mob qis los ntawm inhibiting dihydroorotate dehydrogenase (tus nqi txiav txim siab enzyme rau synthesis ntawm UMP), txo DNA thiab RNA synthesis, thiab ntes lub cell proliferation voj voog thiab tsim cov tshuaj tiv thaiv.Kev txo qis ntawm dihydroorotate rau orotate tshwm sim nrog kev txo qis ntawm nws cov cofactor, ubiquinone (coenzyme Q).Qhov inhibition ntawm dihydroorotate dehydrogenase los ntawm teriflunomide qhia tias tsis muaj kev sib tw thiab tsis sib tw kinetics.Kev tswj hwm ntawm leflunomide hauv cov neeg mob rheumatoid mob caj dab ua rau muaj kev tshem tawm ntawm B hlwb thiab txo qis ntawm kev tiv thaiv kab mob.

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Kev sib xyaw	C12H9F3N2O2
Assay	99%
Qhov tshwm sim	Dawb hmoov
CAS Nr.	75706-12-6
Ntim	25 KG
Txee lub neej	2 xyoo
Cia	Khaws rau hauv qhov chaw txias thiab qhuav
Daim ntawv pov thawj	ISO.