L-Lactate dehydrogenase CAS: 9001-60-9

Qhov cuam tshuam ntawm L-Lactate dehydrogenase (LDH) suav nrog nws lub luag haujlwm hauv kev hloov pauv lub zog ntawm lub cev thiab nws txoj kev koom tes hauv kev hloov pauv ntawm pyruvate mus rau lactate. LDH pab tswj kev sib npaug ntawm lub zog hauv cov hlwb los ntawm kev pab txhawb kev hloov pauv ntawm pyruvate, ib qho khoom lag luam ntawm kev hloov pauv glucose, mus rau hauv lactate. Cov txheej txheem no, hu ua anaerobic glycolysis, tshwm sim thaum cov pa oxygen tsawg.

LDH kuj tseem ua lub luag haujlwm tseem ceeb hauv kev siv lactate rov qab. Thaum lub sijhawm ua si hnyav lossis thaum muaj oxygen tsawg, lactate tuaj yeem sib sau ua ke hauv cov ntaub so ntswg. LDH pab rov ua dua lactate los ntawm kev hloov nws rov qab mus rau pyruvate, uas tom qab ntawd tuaj yeem siv ua lub hauv paus rau kev tsim hluav taws xob lossis hloov mus ua glucose los ntawm gluconeogenesis. Lub tshuab rov ua dua lactate no tso cai rau cov hlwb siv lactate ua lub zog tau zoo thiab pab tiv thaiv kev sib sau ua ke ntawm lactate, uas tuaj yeem ua rau lub hlwb ua haujlwm tsis zoo.

LDH muaj ntau daim ntawv thov hauv kev kho mob. Ib qho ntawm nws cov ntawv thov tseem ceeb yog ua ib qho cim qhia txog qee yam kab mob. Cov theem siab ntawm LDH hauv cov ntshav tuaj yeem qhia txog kev puas tsuaj ntawm cov nqaij lossis muaj cov kab mob xws li kev puas tsuaj rau daim siab, myocardial infarction, thiab qee hom mob qog noj ntshav. Cov theem LDH feem ntau raug saib xyuas hauv cov chaw kho mob kom ntsuas qhov kev nce qib ntawm tus kab mob thiab kev teb rau kev kho mob.