Glucose-6-Phosphate Dehydrogenase CAS: 9001-40-5

Kev Hloov Pauv ntawm Lub Cev: G6PD koom nrog txoj kev hloov pauv ntawm cov piam thaj hauv lub cev, tshwj xeeb yog txoj kev hloov pauv ntawm pentose phosphate. Nws ua rau muaj kev hloov pauv ntawm glucose-6-phosphate mus rau 6-phosphogluconolactone, tsim NADPH hauv cov txheej txheem. NADPH yog ib qho tseem ceeb rau ntau yam txheej txheem ntawm lub cev, suav nrog kev tiv thaiv antioxidant, biosynthesis ntawm cov rog thiab cov roj cholesterol, thiab tswj kev sib npaug ntawm cov redox hauv lub cev.

Kev Tiv Thaiv Antioxidant: NADPH uas G6PD tsim tawm yog qhov tseem ceeb rau kev tsim cov glutathione txo qis (GSH), uas yog ib qho tseem ceeb ntawm cov tshuaj antioxidant. GSH tiv thaiv cov hlwb ntawm kev ntxhov siab oxidative los ntawm kev ua kom cov free radicals thiab cov reactive oxygen species (ROS) tsis muaj zog. G6PD deficiency tuaj yeem ua rau muaj NADPH thiab txo qhov ua tau zoo ntawm kev tiv thaiv antioxidant, ua rau muaj kev cuam tshuam ntau ntxiv rau kev puas tsuaj oxidative.

Kab mob ntshav tsis txaus: G6PD deficiency yog qhov tsis txaus enzyme feem ntau thoob ntiaj teb. Nws feem ntau cuam tshuam rau cov txiv neej thiab tuaj yeem ua rau muaj kab mob ntshav tsis txaus, uas yog ib qho mob uas ua rau cov qe ntshav liab puas tsuaj. Qee yam ua rau, xws li kev kis kab mob, qee yam tshuaj (piv txwv li, tshuaj tua kab mob malaria, tshuaj sulfa), thiab qee yam khoom noj (piv txwv li, taum fava), tuaj yeem ua rau cov neeg uas muaj G6PD deficiency hemolysis. Qhov tsis txaus no ua rau lawv tsis muaj peev xwm tswj hwm cov kev ntxhov siab oxidative uas tsim los ntawm cov ua rau no, ua rau cov qe ntshav liab tawg.

Kev Tshuaj Kho Mob: Kev tshuaj xyuas G6PD yog qhov tseem ceeb hauv kev kho mob kom tiv thaiv kev tsis haum tshuaj. Qee cov tshuaj, xws li qee cov tshuaj tiv thaiv kab mob malaria (piv txwv li, primaquine) thiab tshuaj tua kab mob (piv txwv li, sulfonamides), tuaj yeem ua rau cov neeg uas muaj G6PD tsis txaus hemolysis. Kev tshuaj xyuas ua ntej rau G6PD tsis txaus pab txheeb xyuas cov tib neeg uas muaj kev pheej hmoo thiab tuaj yeem coj kev xaiv cov tshuaj lossis siv lwm txoj kev kho mob los tiv thaiv cov mob hemolytic hnyav.