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Adenosine CAS: 58-61-7
Adenosine yog ib qho nucleoside uas muaj adenine thiab ribose, ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm lub cev. Nws ua haujlwm ua lub hauv paus tseem ceeb rau adenosine triphosphate (ATP), lub zog tseem ceeb hauv cov kab ke hauv lub cev. Dhau li ntawm nws cov haujlwm ntsig txog lub zog, adenosine koom nrog ntau yam txheej txheem ntawm lub cev, suav nrog kev xa xov ntawm lub paj hlwb, kev nthuav dav ntawm cov hlab ntsha, thiab kev tswj hwm ntawm lub voj voog pw tsaug zog. Nws ua haujlwm rau cov receptors tshwj xeeb, cuam tshuam rau lub plawv dhia thiab cov ntshav ntws. Hauv kev kho mob, adenosine siv rau hauv tshuaj, tshwj xeeb tshaj yog hauv kev kho mob ntawm qee yam mob plawv dhia tsis xwm yeem. Nws lub luag haujlwm ntau yam qhia txog qhov tseem ceeb ntawm adenosine hauv kev noj qab haus huv thiab kab mob.
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Uridine 5-monophosphate, disodium ntsev CAS: 3387-36-8
Uridine 5-monophosphate, disodium ntsev (UMP) yog ib qho nucleotide uas ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm lub cev thiab RNA synthesis. Muaj cov pyrimidine base uracil, ib qho ribose qab zib, thiab ib pawg phosphate, UMP yog qhov tseem ceeb rau ntau yam txheej txheem biological, suav nrog kev tsim cov nucleic acids thiab kev tswj hwm ntawm cov txheej txheem metabolic. Cov ntsev disodium ua rau nws cov solubility thiab kev ruaj khov hauv cov kua dej, ua rau nws tsim nyog rau kev tshawb fawb hauv chaw kuaj mob thiab kev siv tshuaj kho mob. UMP tau txais kev saib xyuas rau nws cov peev xwm neuroprotective thiab kev txhim kho kev paub, nrog rau nws lub luag haujlwm hauv kev txhawb nqa kev noj qab haus huv ntawm lub cev tag nrho.
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Cytidine 5′-(disodium phosphate) CAS: 6757-06-8
Cytidine 5′-(disodium phosphate) yog ib qho nucleotide derivative uas muaj cov pyrimidine base cytosine, ribose sugar, thiab ib pawg phosphate. Cov compound no ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem biochemical, suav nrog RNA synthesis, regulatory pathways, thiab cellular signaling. Cov disodium ntsev daim ntawv ua rau nws cov solubility thiab stability hauv physiological mob, ua rau nws tsim nyog rau kev tshawb fawb hauv chav kuaj thiab cov kev siv kho mob. Cytidine 5′-(disodium phosphate) tau txais kev txaus siab rau nws txoj kev koom tes hauv nucleic acid metabolism thiab nws cov txiaj ntsig zoo hauv kev txhim kho kev ua haujlwm ntawm lub hlwb thiab txhawb nqa kev noj qab haus huv ntawm lub hlwb.
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5-Azacytidine CAS: 320-67-2
5-Azacytidine yog ib qho nucleoside analogue ntawm cytidine uas muaj ib qho nitrogen atom nyob rau hauv 5-txoj hauj lwm ntawm lub nplhaib pyrimidine, hloov ib qho carbon atom. Qhov kev hloov kho no muab cov khoom tshwj xeeb pharmacological, ua rau nws yog ib qho tseem ceeb hauv molecular biology thiab kev kho mob qog noj ntshav. Raws li ib qho muaj zog DNA methyltransferase inhibitor, 5-azacytidine tuaj yeem rov ua kom cov noob caj noob ces ntsiag to los ntawm kev hloov cov qauv DNA methylation, yog li cuam tshuam rau kev qhia noob caj noob ces. Chiv thawj tsim los kho cov kab mob hematologic, 5-azacytidine tau txais kev saib xyuas rau nws cov ntawv thov hauv epigenetic therapy, regenerative tshuaj, thiab kev tshawb fawb tsom mus rau ntau yam kab mob uas muaj cov yam ntxwv ntawm kev tswj hwm noob caj noob ces tsis zoo.
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2′-Fluoro-2′-deoxyuridine CAS: 784-71-4
2′-Fluoro-2′-deoxyuridine (FdU) yog ib qho nucleoside analog ntawm deoxyuridine, qhov twg lub hydrogen atom ntawm 2′ txoj hauj lwm ntawm ribose qab zib hloov los ntawm lub fluorine atom. Qhov kev hloov kho no ua rau kom muaj kev ruaj khov thiab bioactivity ntawm cov tshuaj, ua rau nws muaj txiaj ntsig zoo rau kev tshawb fawb biochemical thiab kev siv kho mob. FdU yog paub tshwj xeeb rau nws lub luag haujlwm ua tus neeg sawv cev tiv thaiv kab mob thiab tiv thaiv kab mob qog noj ntshav, vim nws tuaj yeem cuam tshuam nrog DNA synthesis thiab tiv thaiv kev rov ua dua ntawm qee cov kab mob thiab cov hlwb qog noj ntshav. Nws cov khoom tshwj xeeb ua rau nws yog ib qho cuab yeej tseem ceeb hauv kev tsim cov kev kho mob tsom mus rau thiab kev tshawb fawb txog molecular biology.
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![4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-ib CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-ib CAS:10212-20-1
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-ib yog ib qho nucleoside analog uas muaj pyrimidine puag txuas nrog rau cov suab thaj ribose hloov kho. Qhov muaj cov fluorine atom thiab hydroxyl pawg hauv nws cov qauv txhim kho nws cov khoom biochemical, ua rau nws yog ib tus neeg sib tw nthuav rau kev tshawb fawb txog kev tiv thaiv kab mob thiab kev tiv thaiv kab mob qog noj ntshav. Cov tshuaj no muaj peev xwm siv tau hauv kev kho mob tshuaj, tshwj xeeb tshaj yog ua tus neeg sawv cev kho mob uas tsom mus rau kev tsim cov nucleic acid thiab cov txheej txheem metabolic hauv cov kab mob pathogenic. Nws cov yam ntxwv tshwj xeeb tso cai rau kev sib cuam tshuam zoo dua nrog cov hom phiaj biological koom nrog hauv DNA thiab RNA metabolism.
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1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS: 22224-41-5
1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose yog ib hom tshuaj ribose uas tau hloov kho, muaj peb pawg benzoyloxy txuas rau 1, 3, thiab 5 qhov chaw ntawm cov qauv ribofuranose. Qhov kev hloov kho no ua rau nws cov solubility thiab kev ruaj khov zoo dua, ua rau nws muaj txiaj ntsig zoo rau ntau yam kev siv tshuaj hauv cov organic chemistry thiab biochemistry. Ua ib qho kev tiv thaiv ntawm ribose, nws ua haujlwm ua ib qho nruab nrab hauv kev tsim cov nucleosides thiab nucleotides, cov khoom tseem ceeb ntawm RNA thiab DNA. Nws cov khoom tshwj xeeb ua rau 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose muaj txiaj ntsig zoo rau cov kws tshawb fawb nrhiav kev tsim cov neeg sawv cev kho mob tshiab thiab cov ntaub ntawv hauv nucleotide chemistry.
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2′-O-methyluridine CAS: 2140-76-3
2′-O-Methyluridine yog ib qho nucleoside uas tshwm sim ntuj uas ib pawg methyl txuas rau lub atom oxygen ntawm 2′ txoj haujlwm ntawm ribose qab zib hauv uridine. Qhov kev hloov kho no ua rau muaj kev ruaj khov thiab kev ua haujlwm ntawm RNA molecules, ua rau nws yog ib qho tseem ceeb hauv ntau yam txheej txheem biological. 2′-O-Methyluridine ua lub luag haujlwm tseem ceeb hauv cov qauv thiab kev ua haujlwm ntawm ribonucleic acids (RNAs), suav nrog messenger RNA (mRNA) thiab hloov RNA (tRNA). Nws qhov muaj nyob tuaj yeem cuam tshuam rau RNA kev ruaj khov, kev txhais lus zoo, thiab kev sib cuam tshuam nrog cov protein thiab lwm yam nucleic acids, ua rau nws yog ib qho tseem ceeb hauv kev kawm txog molecular biology thiab kev siv tshuaj kho mob.
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adenosine 5′-monophosphate sodium * los ntawm poov xab CAS: 4578-31-8
Adenosine 5′-monophosphate sodium (AMP) yog ib qho nucleotide uas tau los ntawm adenosine uas ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm lub cev. AMP yog qhov tseem ceeb rau ntau yam txheej txheem ntawm lub cev, suav nrog kev hloov pauv zog, kev hloov pauv teeb liab, thiab ua tus ua ntej rau kev tsim ATP thiab lwm yam nucleotides. Daim ntawv ntsev sodium ntawm AMP tuaj yeem tau los ntawm cov poov xab, uas muaj ntau yam nucleotides vim nws txoj kev ua haujlwm ntawm lub cev. Cov tshuaj no feem ntau siv hauv biochemistry thiab pharmacology ua cov tshuaj biochemical reagent, cov khoom noj khoom haus ntxiv, thiab cov khoom noj khoom haus ntxiv, vim nws muaj txiaj ntsig zoo rau kev noj qab haus huv thiab kev siv hauv kev txhawb nqa kev ua haujlwm ntawm lub cev.
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2′-Deoxycytidine CAS: 951-77-9
2′-Deoxycytidine yog ib qho nucleoside uas muaj cov suab thaj deoxyribose thiab cytosine, uas txawv ntawm qhov tsis muaj pawg hydroxyl ntawm 2′ txoj haujlwm ntawm ribose. Qhov kev hloov kho no ua rau nws yog ib qho tseem ceeb ntawm DNA, qhov twg nws ua khub nrog guanine thaum lub sijhawm sib txuas ua ke. 2′-Deoxycytidine ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm lub cev thiab kev tsim DNA, ua lub hauv paus rau deoxycytidine triphosphate (dCTP), uas yog qhov tseem ceeb rau kev rov ua dua thiab kho DNA. Tsis tas li ntawd, cov nucleoside no muaj cov txiaj ntsig tseem ceeb hauv kev tshawb fawb txog molecular biology, kev kho mob qog noj ntshav, thiab cov tswv yim tiv thaiv kab mob, qhia txog nws qhov tseem ceeb hauv kev tshawb fawb tseem ceeb thiab kev siv hauv kev kho mob.
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2,2′-cyclouridine CAS: 3736-77-4
2,2′-Cyclouridine yog ib qho bicyclic nucleoside derivative ntawm uridine, uas yog tus cwj pwm los ntawm kev tsim cov qauv cyclic tshwj xeeb uas cuam tshuam nrog 2′ thiab 2” txoj haujlwm ntawm ribose moiety. Qhov kev hloov kho qauv no muab cov khoom biochemical sib txawv uas cuam tshuam rau nws qhov ruaj khov thiab kev ua haujlwm ntawm lub cev. 2,2′-Cyclouridine tau txais kev txaus siab rau tshuaj lom neeg biology thiab tshuaj lom neeg vim nws cov ntawv thov muaj peev xwm ua tus neeg sawv cev tiv thaiv kab mob thiab hauv kev tshawb fawb RNA. Nws lub peev xwm los hloov kho cov kev sib cuam tshuam nucleic acid ua rau nws yog ib qho cuab yeej muaj txiaj ntsig rau kev kawm txog kev sib raug zoo ntawm RNA qauv-kev ua haujlwm, uas ua rau muaj kev nce qib hauv cov tswv yim kho mob uas tsom mus rau kev kis kab mob thiab cov kab mob caj ces.
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2-Aminoadenosine CAS: 2096-10-8
2-Aminoadenosine yog ib qho nucleoside derivative ntawm adenosine, uas muaj ib pawg amino nyob rau ntawm 2-qhov chaw ntawm ribose qab zib. Qhov kev hloov pauv no hloov pauv nws cov khoom siv biochemical thiab kev ua haujlwm, ua rau nws yog ib qho tseem ceeb hauv ntau yam txheej txheem physiological. 2-Aminoadenosine koom nrog hauv kev sib txuas lus ntawm tes, metabolism, thiab kev tswj hwm txoj kev, suav nrog cov uas cuam tshuam nrog lub zog homeostasis thiab neurotransmission. Nws cov ntawv thov kho mob muaj peev xwm nthuav dav ntau qhov chaw, suav nrog neurobiology thiab cardiology, qhov twg nws yuav cuam tshuam rau cov lus teb ntawm tes rau kev ntxhov siab thiab kev raug mob. Raws li kev tshawb fawb txuas ntxiv mus, 2-aminoadenosine tuav cov lus cog tseg rau kev tsim cov tshuaj bioactive tshiab thiab cov neeg sawv cev kho mob.
