Fidaxomicin CAS: 873857-62-6

Fidaxomicin feem ntau yog siv los kho tus kab mob Clostridioides difficile, tshwj xeeb tshaj yog rau cov neeg mob CDI nruab nrab mus rau hnyav uas cov kev kho mob ib txwm tsis zoo lossis muaj feem rov qab mob ntau. Nws yog noj hauv daim ntawv ntsiav tshuaj, tso cai rau kev xa mus rau qhov chaw muaj kab mob hauv txoj hnyuv. Lub tshuab tshwj xeeb ntawm kev ua haujlwm ntawm fidaxomicin yog inhibiting bacterial RNA polymerase, cuam tshuam kev tsim cov protein hauv C. difficile hlwb. Los ntawm kev tsom mus rau tus kab mob tshwj xeeb no yam tsis cuam tshuam rau cov kab mob hauv plab, fidaxomicin pab rov qab kho qhov sib npaug ntawm cov kab mob hauv txoj hnyuv thiab txo qhov kev pheej hmoo ntawm cov kab mob CDI rov tshwm sim. Cov neeg mob uas tau lees paub lossis xav tias muaj kab mob C. difficile feem ntau raug sau ntawv rau fidaxomicin rau lub sijhawm teev tseg nyob ntawm qhov hnyav ntawm tus kab mob. Kev ua raws li cov tshuaj thiab kev kho mob tau sau tseg yog qhov tseem ceeb rau kev ua tiav cov txiaj ntsig zoo tshaj plaws thiab txo qhov kev pheej hmoo ntawm kev rov qab mob. Cov kev mob tshwm sim feem ntau yuav suav nrog xeev siab, mob plab, thiab teeb meem plab hnyuv; txawm li cas los xij, fidaxomicin feem ntau ua rau muaj kev kam rau siab zoo piv rau lwm yam kev kho mob CDI. Kev saib xyuas tsis tu ncua thaum lub sijhawm kho mob thiab kev soj ntsuam tom qab kho mob yog qhov tseem ceeb rau kev ntsuas kev teb, saib xyuas cov kev tsis zoo, thiab tiv thaiv kev rov qab los ntawm tus kab mob C. difficile. Cov kws kho mob ua lub luag haujlwm tseem ceeb hauv kev coj ua kom siv fidaxomicin kom raug los tswj CDI thiab txhawb kom tus neeg mob rov zoo.