dUMP, 2′-Deoxyuridine-5′-monophosphate, disodium ntsev CAS: 42155-08-8

Kev Tsim DNA: dUMP ua haujlwm ua tus thawj coj rau deoxythymidine triphosphate (dTTP), uas yog qhov tseem ceeb rau kev rov ua dua DNA. Kev hloov pauv ntawm dUMP mus rau dTMP yog ib kauj ruam tseem ceeb hauv kev tsim cov thymidine nucleotides, uas yog qhov tseem ceeb rau kev rov ua dua ntawm cov khoom siv caj ces thaum lub sijhawm faib cell.

Kev Tsim Thymidylate: dUMP yog lub substrate rau cov enzyme thymidylate synthase, uas ua rau kev hloov pauv ntawm dUMP mus rau dTMP. Cov txheej txheem no yog qhov tseem ceeb rau kev tswj hwm qhov sib npaug ntawm nucleotide hauv cov cell thiab xyuas kom meej tias DNA replication muaj tseeb.

Lub Hom Phiaj Tshuaj Tiv Thaiv Kab Mob Cancer: Thymidylate synthase, lub enzyme uas koom nrog kev hloov pauv ntawm dUMP mus rau dTMP, yog lub hom phiaj rau qee cov tshuaj tiv thaiv kab mob cancer. Kev txwv tsis pub thymidylate synthase tuaj yeem cuam tshuam kev tsim DNA thiab kev loj hlob ntawm cov cell, ua rau nws yog lub hom phiaj rau kev kho mob chemotherapy.

Cov Cuab Yeej Tshawb Fawb: dUMP siv rau hauv kev tshawb fawb txog biochemical thiab molecular biology ua ib qho substrate los kawm txog cov txheej txheem ntawm DNA synthesis, kho, thiab nucleotide metabolism. Nws kuj tseem siv rau hauv enzymatic assays los tshawb nrhiav kev ua haujlwm ntawm thymidylate synthase thiab lwm yam enzymes.