Bis (2-chloroethyl) aminehydrochloride CAS: 821-48-7

Bis(2-chloroethyl)amine hydrochloride muaj kev siv tseem ceeb hauv kev kho mob qog noj ntshav thiab kev kho mob qog noj ntshav. Ua ib tus neeg sawv cev alkylating, nws cuam tshuam nrog DNA replication thiab cell division, ua rau nws cytotoxic rau cov hlwb sai sai proliferating, suav nrog cov hlwb qog noj ntshav. Cov khoom no tau ua rau muaj kev tsim cov nitrogen mustarps ua cov neeg sawv cev chemotherapeutic rau kev kho ntau yam kab mob neoplastic. Ib qho ntawm kev siv tseem ceeb ntawm bis(2-chloroethyl)amine hydrochloride yog nyob rau hauv kev kho mob ntawm qee hom qog noj ntshav, xws li lymphoma, leukemia, thiab cov qog nqaij hlav khov kho. Los ntawm kev ua puas tsuaj rau DNA ntawm cov hlwb qog noj ntshav, cov tshuaj no tuaj yeem ua rau cov hlwb tuag thiab tiv thaiv kev loj hlob ntawm cov qog noj ntshav, pab kom me me lossis tshem tawm cov qog nqaij hlav malignant hauv cov ntaub so ntswg cuam tshuam. Ntxiv mus, bis(2-chloroethyl)amine hydrochloride yog siv hauv cov chaw soj nstuam tshawb fawb los kawm txog cov txheej txheem ntawm kev ua haujlwm ntawm cov neeg sawv cev alkylating thiab tshawb nrhiav lawv cov kev siv kho mob. Cov kws tshawb fawb tshawb nrhiav kev sib cuam tshuam molecular ntawm nitrogen mustards thiab cov khoom ntawm tes los txhim kho cov tswv yim kho mob qog noj ntshav thiab tsim cov tshuaj zoo dua. Ntxiv mus, cov tshuaj no yog siv rau hauv kev tshawb fawb preclinical thiab kev sim tshuaj los ntsuas nws cov txiaj ntsig thiab kev nyab xeeb rau cov neeg mob qog noj ntshav. Los ntawm kev soj ntsuam cov ntaub ntawv tshuaj thiab kev ua haujlwm tiv thaiv qog ntawm bis(2-chloroethyl)amine hydrochloride, cov kws tshawb fawb lub hom phiaj yog los tsim nws lub luag haujlwm hauv kev kho mob niaj hnub no thiab ua kom zoo dua cov kev kho mob rau cov kab mob qog nqaij hlav tshwj xeeb. Hauv kev xaus, bis(2-chloroethyl)amine hydrochloride ua lub luag haujlwm tseem ceeb hauv kev kho mob qog nqaij hlav thiab kev tshawb fawb biomedical, muab cov hauv kev tshiab rau kev tawm tsam cov kab mob qog nqaij hlav thiab txhim kho peb txoj kev nkag siab txog cov neeg sawv cev tiv thaiv qog nqaij hlav. Nws cov tshuaj lom xaiv rau cov hlwb qog nqaij hlav qhia txog nws qhov tseem ceeb hauv kev tsim cov kev kho mob tshiab rau kev txhim kho cov txiaj ntsig ntawm tus neeg mob thiab lub neej zoo.