Acetylcholinesterase CAS: 9000-81-1

Qhov ua haujlwm anticholinesterase yog hais txog lub peev xwm ntawm qee cov tshuaj lossis cov tshuaj lom neeg los txwv tsis pub cov enzyme acetylcholinesterase ua haujlwm. Acetylcholinesterase yog lub luag haujlwm rau kev rhuav tshem cov neurotransmitter acetylcholine hauv lub cev. Los ntawm kev txwv cov enzyme no, anticholinesterases ua rau cov acetylcholine ntau ntxiv, ua rau muaj kev ua haujlwm cholinergic ntau ntxiv.

Kev siv tshuaj anticholinesterases tseem ceeb yog siv rau kev kho mob ntawm cov mob uas muaj cov cholinergic tsawg. Cov no suav nrog cov kab mob neurological xws li Alzheimer's tus kab mob thiab myasthenia gravis. Hauv Alzheimer's tus kab mob, cov tshuaj anticholinesterases xws li donepezil, rivastigmine, thiab galantamine yog siv los tiv thaiv kev tawg ntawm acetylcholine thiab txhim kho cholinergic neurotransmission. Qhov no tuaj yeem pab txhim kho kev ua haujlwm ntawm lub hlwb thiab tej zaum yuav qeeb qeeb qhov kev loj hlob ntawm tus kab mob.

Hauv cov neeg mob myasthenia gravis, cov tshuaj anticholinesterases xws li neostigmine thiab pyridostigmine yog siv los txhim kho kev sib kis ntawm cov leeg nqaij. Cov tshuaj no inhibit acetylcholinesterase thiab ua rau cov acetylcholine ntau ntxiv ntawm qhov sib txuas ntawm cov leeg nqaij, ua kom cov leeg muaj zog thiab txo cov leeg tsis muaj zog.

Cov tshuaj Anticholinesterases kuj muaj kev siv rau kev kuaj mob thiab kev kho mob hauv cov xwm txheej ntawm kev lom tshuaj anticholinergic. Cov tshuaj Anticholinergic, xws li qee cov tshuaj tua kab lossis cov tshuaj ua rau cov hlab ntsha, tuaj yeem ua rau muaj kev thaiv cholinergic ntau dhau ua rau muaj cov tsos mob xws li kev tsis meej pem, lub plawv dhia ceev, qhov ncauj qhuav, thiab pom kev tsis meej. Hauv cov xwm txheej zoo li no, cov tshuaj anticholinesterases xws li pralidoxime tuaj yeem siv los thim rov qab cov teebmeem los ntawm kev nce qib acetylcholine thiab sib tw nrog cov tshuaj lom.