(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid CAS:30246-33-4

(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, tseem hu ua [sau lub npe lag luam lossis lub npe dav dav yog tias siv tau], muaj qhov tseem ceeb hauv kev tshawb fawb txog tshuaj thiab kev tsim tshuaj vim nws cov khoom siv tua kab mob. Cov tshuaj no ua haujlwm ua lub hauv paus tseem ceeb rau kev tsim cov tshuaj tua kab mob uas tsim los rau cov kab mob tshwj xeeb thiab tiv thaiv lawv txoj kev loj hlob. Nws cov qauv tsim tso cai rau kev sib cuam tshuam meej nrog cov enzymes kab mob, cuam tshuam cov txheej txheem tseem ceeb thiab ua rau muaj cov teebmeem bactericidal. Ntxiv mus, (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid ua lub luag haujlwm tseem ceeb hauv kev tawm tsam cov kab mob uas ua rau muaj kev hem thawj rau tib neeg kev noj qab haus huv. Los ntawm kev koom ua ke cov tshuaj no rau hauv cov tshuaj tua kab mob, cov kws tshawb fawb tsom mus rau kev tsim cov kev xaiv kho mob tshiab nrog kev ua haujlwm zoo dua thiab txo qis kev tiv thaiv. Cov txheej txheem ua haujlwm ntawm cov tshuaj no tsom mus rau cov phab ntsa ntawm cov kab mob lossis cov protein synthesis, muab ntau yam kev ua haujlwm tawm tsam ob qho tib si Gram-positive thiab Gram-negative bacteria, suav nrog ntau hom tshuaj tiv thaiv kab mob. Ntxiv mus, kev tshawb fawb tsom mus rau kev ua kom zoo dua cov khoom pharmacokinetic ntawm (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid los txhim kho nws cov bioavailability thiab kev faib tawm hauv lub cev. Cov txheej txheem kev ua kom zoo dua no suav nrog kev tshawb nrhiav ntau yam tswv yim xa tshuaj, xws li prodrugs, nanoparticles, lossis liposomal formulations, los txhim kho cov tshuaj kho mob thiab txo cov kev mob tshwm sim. Xaus lus, (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid sawv cev rau ib qho khoom muaj nqis hauv kev kho mob sib kis, muab cov kev daws teeb meem zoo rau kev daws teeb meem kev tiv thaiv kab mob thiab txhim kho cov txiaj ntsig ntawm tus neeg mob. Nws cov ntawv thov ntau yam hauv kev kho mob tshuaj tua kab mob qhia txog nws qhov tseem ceeb hauv kev kho mob niaj hnub no thiab qhia txog nws lub peev xwm los tsav kev tsim kho tshiab hauv kev tsim cov tshuaj tua kab mob tiam tom ntej.