(2R,4S)-4-Aminopyrrolidin-2-carboxylic acid CAS: 263407-17-6

(2R,4S)-4-Aminopyrroliden-2-carboxylic acid ua lub luag haujlwm tseem ceeb ua ib qho nruab nrab hauv kev tsim cov tshuaj sib xyaw ua ke, cov tshuaj bioactive nrog cov ntawv thov tshuaj. Nws txoj kev koom ua ke rau hauv cov qauv molecular ua rau cov kws tshawb fawb tshawb nrhiav cov neeg sib tw tshuaj tshiab uas tsom mus rau thaj chaw kho mob xws li cov neeg sawv cev antiviral, enzyme inhibitors, lossis peptidomimetics. Qhov muaj chiral pyrrolidine core thiab cov amino acid functionality qhia txog cov tshuaj reactivity thiab pharmacophoric tshwj xeeb, ua rau nws muaj txiaj ntsig zoo rau kev tshawb fawb txog tshuaj. Hauv kev siv zog tshawb nrhiav tshuaj, cov tshuaj no tuaj yeem ua lub hauv paus pib rau kev tsim cov neeg sib tw tshuaj, siv nws cov yam ntxwv ntawm cov qauv los hloov kho cov haujlwm biological thiab cov khoom pharmacokinetic. Tsis tas li ntawd, qhov xwm txheej chiral ntawm lub molecule tuaj yeem cuam tshuam nws cov kev sib cuam tshuam nrog cov hom phiaj biological, uas tuaj yeem cuam tshuam nws cov khoom pharmacological thiab txhim kho nws cov txiaj ntsig hauv kev tsim tshuaj. Ntxiv mus, hauv kev kawm thiab kev lag luam, cov kws tshawb fawb tuaj yeem siv lub tsev thaiv no los npaj cov tsev qiv ntawv ntawm ntau yam derivatives rau kev tshawb fawb txog kev sib raug zoo ntawm cov qauv thiab kev ua ub no, pab txhawb kev txheeb xyuas cov tshuaj txhuas nrog cov teebmeem biological xav tau. Nws lub luag haujlwm hauv kev tsim tshuaj lom neeg txuas ntxiv mus rau kev tsim cov tshuaj intermediates thiab kev tsim cov txheej txheem tsim tshiab, qhia txog nws cov txiaj ntsig dav dav thoob plaws kev tshawb fawb. Zuag qhia tag nrho, (2R, 4S) -4-Aminopyrrolidine-2-carboxylic acid ua lub luag haujlwm tseem ceeb hauv kev nrhiav kev tshawb pom tshuaj tshiab thiab kev tshawb fawb txog tshuaj lom neeg, muab lub platform rau kev tsim cov tshuaj lom neeg ntau yam thiab cov tshuaj intermediates.