(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride CAS:188416-35-5

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride siv rau hauv kev kho mob rau nws cov haujlwm pharmacological thiab kev siv kho mob. Cov tshuaj no yuav ua rau pom cov khoom tiv thaiv kev loj hlob, tiv thaiv kev o, lossis enzyme inhibitory uas muaj txiaj ntsig zoo rau kev kho mob ntawm ntau yam kab mob, suav nrog mob qog noj ntshav, mob o, thiab mob sib kis. Hauv kev tshawb nrhiav tshuaj, cov kws tshawb fawb siv (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride los tsim thiab tsim cov tshuaj tshiab nrog kev muaj zog, kev xaiv, thiab bioavailability zoo dua. Los ntawm kev hloov kho nws cov qauv tshuaj thiab tshawb nrhiav kev sib raug zoo ntawm cov qauv thiab kev ua haujlwm, cov kws tshawb fawb lub hom phiaj yog tsim cov neeg sawv cev kho mob tshiab uas tsom mus rau cov kab mob molecular tshwj xeeb thiab cov hom phiaj biological uas cuam tshuam rau cov kab mob. Ntxiv mus, cov tshuaj no ua haujlwm ua lub hauv paus molecular rau kev tsim cov tshuaj muaj peev xwm nrog cov qauv pharmacokinetic zoo tshaj plaws thiab kev kho mob zoo dua. Nws cov kev sib cuam tshuam nrog cov hom phiaj ntawm tes, cov kev taw qhia, thiab cov cim qhia kab mob muab kev nkag siab txog nws cov teebmeem ntawm lub cev thiab cov txheej txheem ua haujlwm, coj kev tsim cov kev kho mob uas tsom mus rau thiab kev kho mob rau cov neeg mob uas tsis tau txais kev pab kho mob. Ntxiv mus, (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride tuaj yeem siv rau hauv kev tshawb fawb ua ntej los ntsuas nws qhov kev nyab xeeb, kev ua tau zoo, thiab cov khoom siv tshuaj ua ntej mus rau kev sim tshuaj. Nws cov bioactivity, pharmacodynamic cov teebmeem, thiab cov kev mob tshwm sim tau raug soj ntsuam los txiav txim siab nws lub peev xwm kho mob thiab kev tsim nyog rau kev txhim kho ntxiv ua cov khoom siv tshuaj. Zuag qhia tag nrho, (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride sawv cev rau cov khoom muaj nqis hauv kev tshawb fawb txog tshuaj, muab cov sijhawm rau kev tshawb pom tshuaj, kev ua kom zoo dua qub, thiab kev kho mob tshiab hauv kev nrhiav kev daws teeb meem kev kho mob nyuaj thiab txhim kho cov txiaj ntsig ntawm tus neeg mob.