1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile CAS:2158267-70-8

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile ua lub luag haujlwm tseem ceeb ua ib qho nruab nrab hauv kev tsim cov tshuaj sib xyaw ua ke, cov tshuaj bioactive nrog cov ntawv thov tshuaj. Nws kev koom ua ke rau hauv cov qauv molecular ua rau cov kws tshawb fawb tshawb nrhiav cov tshuaj tshiab uas tsom mus rau ntau qhov chaw kho mob xws li kinase inhibitors, fluorescent probes, lossis cov ntawv thov tshuaj lom neeg. Qhov muaj pyrazole core thiab dioxaborolane pawg qhia txog kev ua haujlwm tshwj xeeb thiab cov khoom pharmacophoric, ua rau nws muaj txiaj ntsig zoo rau kev tshawb fawb tshuaj lom neeg. Hauv kev siv zog nrhiav tshuaj, cov tshuaj no tuaj yeem ua lub hauv paus rau kev tsim cov tshuaj muaj peev xwm, siv nws cov yam ntxwv ntawm cov qauv los hloov kho cov haujlwm biological thiab cov khoom pharmacokinetic. Tsis tas li ntawd, dioxaborolane functional pawg muab cov sijhawm rau kev ntxiv derivatization thiab cross-coupling chemistry, tej zaum yuav ua rau kev txhim kho cov tshuaj molecules tshiab nrog cov khoom biological txhim kho thiab cov qauv pharmacokinetic txhim kho. Ntxiv mus, hauv kev kawm thiab kev lag luam, cov kws tshawb fawb tuaj yeem siv lub tsev no los npaj cov tsev qiv ntawv ntawm ntau yam derivatives rau kev tshawb fawb txog kev sib raug zoo ntawm cov qauv thiab kev ua ub no, pab txhawb kev txheeb xyuas cov tshuaj txhuas nrog cov teebmeem biological xav tau. Nws lub luag haujlwm hauv kev tsim tshuaj lom neeg nthuav dav mus rau kev tsim cov tshuaj intermediates thiab kev tsim cov txheej txheem tsim tshiab, qhia txog nws cov txiaj ntsig dav dav thoob plaws kev tshawb fawb. Zuag qhia tag nrho, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile ua lub luag haujlwm tseem ceeb hauv kev nrhiav kev tshawb pom tshuaj tshiab thiab kev tshawb fawb txog tshuaj lom neeg, muab lub platform rau kev tsim cov tshuaj lom neeg ntau yam thiab cov tshuaj intermediates.