Bet-Nicotinamide Mononucleotide CAS: 1094-61-7

β-Nicotinamide mononucleotide (NMN) yog siv los kawm txog kev sib khi motifs hauv RNA aptamers thiab ribozyme activation txheej txheem uas muaj β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.NMN yog ib qho nucleotide muab tau los ntawm ribose thiab nicotinamide.Niacinamide (nicotinamide,) yog ib qho derivative ntawm vitamin B3, tseem hu ua niacin.) Raws li biochemical precursor ntawm NAD +, nws yuav pab tau rau kev tiv thaiv ntawm pellagra.
β-Nicotinamide mononucleotide yog ib qho nruab nrab hauv biosynthesis ntawm nicotinamide adenine dinucleotide (NAD +).Nicotinamide phosphoribosyltransferase (Nampt) catalyzes condensation ntawm nicotinamide nrog 5-phosphoribosyl-1-pyrophosphate los tsim β-NMN, uas yog tom qab hloov mus rau NAD + los ntawm β-NMN adenyltransferase.At 50 μM-1. NAD biosynthesis thiab glucose-stimulated insulin secretion hauv Nampt +/- nas qauv ntawm cov kab mob metabolic, qhia lub luag haujlwm rau Nampt hauv β cell muaj nuj nqi.