Tofacitinib CAS: 477600-75-2 Chaw tsim tshuaj paus

Tofacitinib yog ib qho tshuaj rau kev kho mob rheumatoid mob caj dab (RA), psoriasis, kab mob plab hnyuv, thiab lwm yam kab mob tiv thaiv kab mob, nrog rau kev tiv thaiv kev hloov pauv hauv nruab nrog cev.Nws yog ib qho inhibitor ntawm enzyme Janus kinase 3 (JAK3), uas txhais tau hais tias nws cuam tshuam nrog JAK-STAT teeb liab txoj hauv kev uas xa cov ntaub ntawv sab nraud ntawm tes mus rau hauv lub cell nucleus, cuam tshuam DNA transcription.Tsis ntev los no nws tau pom nyob rau hauv ib tug murine qauv ntawm tsim kev mob caj dab, tofacitinib sai txhim kho tus kab mob los ntawm inhibiting zus tau tej cov inflammatory mediators thiab suppressing STAT1-dependent noob nyob rau hauv cov ntaub so ntswg. txoj hauv kev, qhia tias tofacitinib tuaj yeem siv cov txiaj ntsig kho mob los ntawm txoj hauv kev uas tsis yog tshwj xeeb rau inhibition ntawm JAK3.