Clascoterone CAS: 19608-29-8 Chaw tsim tshuaj paus

Clascoterone yog ib qho androgen receptor inhibitor raug tsim los ua cov tshuaj pleev ib ce thiab kev daws teeb meem los ntawm Cassiopea (lub tuam txhab spin-out ntawm Cosmo Pharmaceuticals) rau kev kho mob ntawm androgen-dependent ntawm daim tawv nqaij, nrog rau androgenetic alopecia thiab pob txuv vulgaris.Txawm hais tias qhov tseeb mechanism ntawm kev txiav txim ntawm clascoterone rau kev kho mob ntawm pob txuv vulgaris yog tsis paub, cov tshuaj ntseeg tau los sib tw nrog androgen dihydrotestosterone rau khi rau androgen receptors nyob rau hauv cov qog sebaceous thiab cov hauv paus plaub hau kom attenuate signaling tsim nyog rau pob txuv pathogenesis.

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Clascoterone yog tsim los ua cov tshuaj pleev ib ce los ntawm Cassiopea rau androgen-dependent ntawm daim tawv nqaij mob.Clascoterone (cortexolone 17α-propionate, CB-03-01) yog ib qho tshiab antagonist ntawm androgen receptors.Nws khi rau androgen receptors nrog siab affinity.Los ntawm kev sib tw nrog androgens rau khi rau androgen receptors, clascoterone ua hauj lwm los ntawm thaiv cov androgen receptor signaling cascades uas txhawb pob txuv pathogenesis, xws li sebaceous qog proliferation, ntau sebum ntau lawm, thiab inflammatory pathways.Thaum Lub Yim Hli 2020, FDA pom zoo clascoterone rau thawj-hauv-chav tshuaj kho pob txuv ( pob txuv vulgaris ) hauv cov txiv neej thiab poj niam cov neeg mob 12 xyoo thiab laus dua.Clascoterone tseem raug tshawb xyuas raws li kev kho tshiab rau androgenetic alopecia.

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Kev sib xyaw	C24H34O5
Assay	99%
Qhov tshwm sim	Dawb hmoov
CAS Nr.	Xyoo 19608-29-8
Ntim	25 KG
Txee lub neej	2 xyoo
Cia	Khaws rau hauv qhov chaw txias thiab qhuav
Daim ntawv pov thawj	ISO.